Exploring new pathways in age-related heart diseases


   Thomas Thum
Hanover Medical School, Institute of Molecular and Translational Therapeutic
Strategies (IMTTS), Hanover, Germany

Leon De Windt, Maastricht University, Maastricht, the Netherlands
Gianluigi Condorelli, Humanitas Research Hospital (HRH), Milan, Italy
Valentín Fuster and Vicente Andreas, Centro Nacional de Investigaciones Cardiovasculares
Carlos III (CNIC), Madrid, SPAIN
Faiez Zannad, University of Lorraine, Inserm-CHU of Nancy, Nancy, France
Alexandrina Burlacu, Institute of Cellular Biology and Pathology “Nicolae Simionescu”,
Bucharest, Romania

Research focus:
EXPERT is aiming at the development of new strategies for the diagnostic and treatment of ageassociated diseases such as heart failure, atherosclerosis and myocardial infarction by exploring non-coding RNA (ncRNA)-mediated regulatory pathways. For a long time regarded as evolutionary junk, ncRNAs are currently emerging as pivotal players in virtually all biological processes. As their levels fluctuate during ageing and disease, ncRNAs are believed to significantly contribute to biodiversity and disease susceptibility including cardiovascular disease. EXPERT will lay the foundation that will lead to novel diagnostic and therapeutic strategies for the treatment of heart failure and other cardiovascular alterations, such as atherosclerosis and myocardial infarction.