Determining the role of clinical and epigenetic risk markers in dilated cardiomyopathies and heart failure


   Hugo A. Katus
University Hospital Heidelberg, Heidelberg, Germany

Andres Metspalu, University of Tartu, Tartu, Estonia
Phillippe Charron, University Hospital Ambroise Paré & Pitié-Salpêtrière, Paris, France
Zofia Bilinska, Institute of Cardiology, Warsaw, Poland
Folkert W. Asselbergs, University Medical Center Utrecht, Utrecht, The Netherlands

Research focus:
Dilated cardiomyopathy is a major cause of heart failure and is the main indication of cardiac transplantation. About 30-50% of the cases can be explained by genetic predisposition. However, the precise mechanisms that lead to variations in disease susceptibility and phenotype presentation including risk for heart failure or sudden cardiac death are thus far unknown. The DETECTIN-HF project will work with selected clinical and molecular markers in a multi-center, multi-national cohort. The facility which arises by creating this single, harmonized portal is unique in setup and scale and is invaluable for research and improved clinical practice.