Heart Failure Rescue by Nutritional Approaches: relevance of mitochondrial substrate utilization


 Borja Ibanez
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain

Silvia G Priori, Istituti Clinici Scientifici Maugeri, Pavia, Italy
Timothy Wai, Necker Enfants Malades Institute, Paris France

Research focus:
Dilated cardiomyopathy is the most common cause of heart failure in the young/middle age population, with no specific treatments. The group of investigators of this project recently demonstrated that a genetic defect leading to mitochondrial dysfunction results in altered cardiac metabolic fuel utilization, dilated cardiomyopathy and heart failure. Interestingly, a diet with very high fat content was able to cure the disease in these mice. FAT4HEART will study the interplay between mitochondrial defects, dietary components and dilated cardiomyopathy as well as the role of specific diet fat contents as a potential therapy for dilated cardiomyopathy.